WBHM – Press release, Sep 23, 2016.
Researchers at UAB have found a new way to create stem cells, one they hope will lead to more efficient and personalized medical treatments. The findings were published Tuesday in Cell Reports.
“In humans, we have more than 200 types of cells,” says Kejin Hu, lead researcher and an assistant professor at the UAB Stem Cell Institute. “But [in] all of these 200 types of cells, they contain the same generic material.”
While there are thousands of genes, any individual cell only expresses some of them. The particular combination of genes determines whether the cell is skin or muscle, for instance.
That process of gene expression starts through what’s called transcription. Transcription is kind of the cell’s way of “reading” the genetic information before going on to do something with it. It’s routine and ongoing, but transcription hits pause when the cell divides.
“How does the cell remember which gene is active, which gene is silenced?” says Hu. “How does the transcription machinery go back to the right place?”
Hu says the cell has protein “bookmarks” so it knows where to pick up after it divides. But instead of allowing the cells to continue on their way, researchers can use chemicals to target these bookmarks and remove them. It’s as if the cell’s memory is wiped clean.
Scientists already knew they could target these bookmarks. But what Hu’s research shows is that once they were gone, cells could more easily be “reprogramed” into another type. They become stem cells.
A Simpler Way
This is not the only way to make stem cells, but Hu says this method is a better than current practices.
Embryonic stem cells come from human embryos. As a result, their use in research generates ethical controversy. Scientists can also create stem cells by transplanting the nucleus of an adult cell into an egg cell. But Hu says this method is technically difficult and only a few labs are capable of performing it successfully.
Hu says targeting the transcriptional bookmarks is simpler and could go a long way to developing personal medical therapies from a individual’s own cells. In theory, doctors could grow tissue or organs and heal our bodies like we repair cars. Using the reprogrammed cells from the patient would also eliminate the risk of rejection that comes with embryonic stem cells.
But Hu cautions we’re nowhere near that yet. He says reprogramming human cells is not efficient enough at this point to use clinically. It also takes more time than the nuclear transfer method.
“We still have a long way as a therapy,” says Hu. “We need a lot of improvement.”
-
yet6zj
-
I was blown away by the quality of this article. The author’s writing is both substantive and engaging, and their commitment to presenting balanced and unbiased perspectives on a range of issues is truly commendable. What I love most about this article is its ability to tackle difficult and controversial issues with sensitivity and nuance, providing readers with a deep and thorough understanding of important social and political issues.
-
0 imaging software at 1 and 2 h after pMCAO from ischemic penumbra of placebo treated black bars and tamoxifen treated white bars animals n 6 per group side effects of clomid male Embryos or fin clips were digested with 100 Ојl 50 mM sodium hydroxide Sigma, incubated at 95 C for 20 minutes and then chilled to 4 C
-
Thank you for your sharing. I am worried that I lack creative ideas. It is your article that makes me full of hope. Thank you. But, I have a question, can you help me?
-
Your point of view caught my eye and was very interesting. Thanks. I have a question for you. https://www.binance.com/zh-TC/register?ref=GJY4VW8W
-
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me. https://accounts.binance.com/ru/register-person?ref=S5H7X3LP
-
Your point of view caught my eye and was very interesting. Thanks. I have a question for you. https://www.binance.com/lv/register?ref=53551167
-
Your article made me suddenly realize that I am writing a thesis on gate.io. After reading your article, I have a different way of thinking, thank you. However, I still have some doubts, can you help me? Thanks.
-
-
After reading your article, I have some doubts about gate.io. I don’t know if you’re free? I would like to consult with you. thank you.
-
After reading your article, I have some doubts about gate.io. I don’t know if you’re free? I would like to consult with you. thank you.
-
Your point of view caught my eye and was very interesting. Thanks. I have a question for you.
-
-
I delight in, lead to I discovered just what I used to be having a look for.
You have ended my 4 day long hunt! God Bless you man. Have
a nice day. Bye -
-
After I initially commented I seem to have clicked the -Notify me when new comments are added- checkbox and from now on whenever a comment is added I receive 4 emails with the exact same comment. Perhaps there is a way you are able to remove me from that service? Appreciate it!
-
-
I have read your article carefully and I agree with you very much. This has provided a great help for my thesis writing, and I will seriously improve it. However, I don’t know much about a certain place. Can you help me? https://www.gate.io/uk/signup/XwNAU
-
-
For latest news you have to pay a visit world-wide-web and on the web I
found this website as a finest web site for hottest updates. -
Reading your article helped me a lot and I agree with you. But I still have some doubts, can you clarify for me? I’ll keep an eye out for your answers.
-
hello everyone. I am planning to start a website with my partner in Australia. But now, later, we get know that a website with the same concept is already exist in UK and they have patent themselves. so does this can cause us a problem. second thing is how we can set the term and conditions and privacy policy. I would be very grateful for your response. thank you.
-
How do I find someones blogger blogs with their email address?
-
I developed a joomla site on my localhost. Now I want to upload it to GoDaddy. How do I do that?
-
Appreciation to my father who told me concerning this blog, this weblog is
truly amazing. -
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me. https://accounts.binance.com/it/register-person?ref=IJFGOAID
-
-
-
-
Thanks to my father who shared with me concerning this web site,
this weblog is actually awesome. -
Push it to the limit cool Wolf you are the best and you can do everything https://www.samsung.com smkmkplobydlmcrjmzgvx
-
I don’t think the title of your article matches the content lol. Just kidding, mainly because I had some doubts after reading the article. https://accounts.binance.com/cs/register?ref=FIHEGIZ8
-
-
Push it to the limit cool Wolf you are the best and you can do everything https://www.samsung.com smkmkplobydlmcrjmzgvx
-
I really lucky to find this website on bing, just what I was looking for : D besides saved to fav.
-
От 25 000 рублей с САЙТА и РЕКЛАМНОЙ КАМПАНИИ. Подробнее по ссылке: https://google.com
-
Howdy, i read your blog occasionally and i own a similar
one and i was just curious if you get a lot
of spam feedback? If so how do you protect against it, any plugin or
anything you can recommend? I get so much lately it’s
driving me insane so any help is very much appreciated. -
Hi to all, the contents present at this site are in fact amazing for people knowledge, well, keep up
the nice work fellows. -
Разрешение на строительство — это официальный документ, предоставляемый официальными ведомствами государственного управления или муниципального руководства, который предоставляет начать стройку или осуществление строительного процесса.
РНС формулирует юридические основания и условия к строительству, включая допустимые категории работ, разрешенные материалы и техники, а также включает строительные нормы и комплекты защиты. Получение разрешения на возведение является обязательным документов для строительной сферы. -
-
-
-
Thank you For your hard work over the years! For this, we give you the opportunity. https://google.com#1234567890 For more information, see the instructions. skfhjvkjsdjsrbhvbsrfhkis
-
-
-
-
Your article gave me a lot of inspiration, I hope you can explain your point of view in more detail, because I have some doubts, thank you.
-
-
-
Attractive sectiion oof content. I just sttumbled uppon your webb ste and
iin axcession cqpital tto asserrt that I acwuire actually enjoyewd account yoiur blo posts.
Anyway I wkll be subscribjng too your augmenbt annd evgen I achievemeent yoou acccess conssistently fast. -
Thhis design iss steller! You most certainly know hhow tto keep a rreader entertained.
Between youur wit aand yourr videos, I was almost movedd to sart mmy own blog
(well, almost…HaHa!) Great job. I rrally njoyed whatt you
hhad too say, and moree than that, howw you presented it.
Too cool! -
Thank you For your hard work over the years! For this, we give you the opportunity. https://google.com#1234567890 For more information, see the instructions. skfhjvkjsdjsrbhvbsrfhkis
-
-
-
Your article gave me a lot of inspiration, I hope you can explain your point of view in more detail, because I have some doubts, thank you.
-
-
-
